Interchemie Macrotyl-250 (960 ml)

Macrotyl-250 Oral

Tilmicosin 25% oral liquid

Composition

Contains per ml:

Tilmicosin (as phosphate)250 mg

Description

Tilmicosin is a broad-spectrum semi-synthetic bactericidal macrolide antibiotic synthesised from tylosin. It has an antibacterial spectrum that is predominantly effective against Mycoplasma spp., Pasteurella spp. and Haemophilus spp., and various Gram-positive organisms such as Corynebacterium spp. It is believed to affect bacterial protein synthesis through binding to 50S ribosomal subunits. Cross-resistance between tilmicosin and other macrolide antibiotics has been observed. Following oral administration, tilmicosin is excreted mainly via the bile into the faeces, with a small proportion being excreted via the urine.

Indications

Macrotyl-250 Oral is indicated for the control and treatment of respiratory infections associated with tilmicosin-susceptible microorganisms such as Mycoplasma spp., Pasteurella multocida, Actinobacillus pleuropneumoniae, Actinomyces pyogenes and Mannheimia haemolytica in calves, pigs, chickens and turkeys.

Contraindications

Hypersensitivity or resistance to tilmicosin.

Concurrent administration of other macrolides or lincosamides.

Administration to animals with an active microbial digestion.

Administration to equine or caprine species.

Parenteral administration, especially in porcine species.

During pregnancy and lactation, use only after a risk/benefit assessment by a veterinarian.

Side Effects

Occasionally, a transient reduction in water or (artificial) milk intake has been observed upon treatment with tilmicosin.

Dosage

For oral administration.

Calves: Twice daily, 1 ml per 20 kg body weight via (artificial) milk for 3 - 5 days.

Pigs: 800 ml per 1000 litres of drinking water (200 ppm) for 5 days.

Poultry: 300 ml per 1000 litres of drinking water (75 ppm) for 3 days.

Note: Medicated drinking water or (artificial) milk should be prepared fresh every 24 h. To ensure a correct dosage, the concentration of the product should be adjusted to the actual fluid intake.

Withdrawal Times

- For meat:

Calves: 42 days.

Pigs: 14 days.

Chickens: 12 days.

Turkeys: 19 days.

Not for use in poultry producing eggs for human consumption.